Publications

A list of publications can be found below, in which the Light Microscopy Facility is acknowledged. Facility users are incited to send a copy of their published work, in which an appropriate acknowledgement is present, to the facility staff in order to keep this list up-to-date.

2019

Small-Molecule Screening in Zebrafish Embryos Identifies Signaling Pathways Regulating Early Thyroid Development.
Haerlingen, B., R. Opitz, I. Vandernoot, A. Trubiroha, P. Gillotay, N. Giusti and S. Costagliola (2019).


Spatiotemporal regulation of multipotency during prostate development.
Tika, E., M. Ousset, A. Dannau and C. Blanpain, Development. (2019).


GPRIN-3 controls neuronal excitability, morphology and striatal-dependent behaviors in the indirect pathway of the striatum.”
Karadurmus, D., D. Rial, J. F. De Backer, D. Communi, A. de Kerchove d’Exaerde and S. N. Schiffmann. J. Neurosci.(2019).


Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways.”
Bonnefont, J., L. Tiberi, van den Ameele, J.,D. Potier, Z.B. Gaber, X. Lin, A. Bilheu, A. Herpoel, F.D. Velez Bravo, F. Guillemot, S. Aerts and P. Vanderhaeghen Neuron (2019).


Route of Infection Strongly Impacts the Host-Pathogen Relationship.
Demars, A., A. Lison, A. Machelart, M. Van Vyve, G. Potemberg, J. M. Vanderwinden, X. De Bolle, J. J. Letesson and E. Muraille, Front Immunol. 2019 Jul 11;10:1589. doi: 10.3389/fimmu.2019.01589. eCollection 2019.


Amyloid-ß pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo.
Vergara C, Houben S, Suain V, Yilmaz Z, De Decker R, Vanden Dries V, Boom A1, Mansour S, Leroy K, Ando K, Brion JP.Acta Neuropathol. 2019 Mar;137(3):397-412. doi: 10.1007/s00401-018-1953-5. Epub 2019 Jan 1.

Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition. Vandenberghe P, Delvaux M, Hagué P, Erneux C, Vanderwinden JM. Oncotarget 10(19): 1798-1811

Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo. Saykali B, Mathiah N, Nahaboo W, Racu ML, Hammou L, Defrance M, Migeotte I. Elife. 2019 Apr 5;8. pii: e42434. doi: 10.7554/eLife.42434. PMID: 30950395

SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma.
Ramos AR, Ghosh S, Dedobbeleer M, Robe PA, Rogister B, Erneux C. FEBS J. 2019 Jan 29. doi: 10.1111/febs.14769. [Epub ahead of print]Lipid phosphatases

2018

Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs.Comhair J1,2, Devoght J2, Morelli G2, Harvey RJ3,4, Briz V5,6, Borrie SC5,6, Bagni C5,6, Rigo JM2, Schiffmann SN1, Gall D1, Brône B2, Molchanova SM1.Front Mol Neurosci. 2018 Oct 15;11:380. doi: 10.3389/fnmol.2018.00380. eCollection 2018.

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy. Sánchez-Danés A, Larsimont JC, Liagre M, Muñoz-Couselo E, Lapouge G, Brisebarre A, Dubois C, Suppa M, Sukumaran V, Del Marmol V, Tabernero J, Blanpain C.Nature. 2018 Oct 8. doi: 10.1038/s41586-018-0603-3. [Epub ahead of print]PMID:    30297799

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases. Fafilek, B., L. Balek, M. K. Bosakova, M. Varecha, A. Nita, T. Gregor, I. Gudernova, J. Krenova, S. Ghosh, M. Piskacek, L. Jonatova, N. H. Cernohorsky, J. T. Zieba, M. Kostas, E. M. Haugsten, J. Wesche, C. Erneux, L. Trantirek, D. Krakow and P. Krejci (2018). Sci Signal 11(548).

Allergic Asthma Favors Brucella Growth in the Lungs of Infected Mice. Machelart, A., G. Potemberg, L. Van Maele, A. Demars, M. Lagneaux, C. De Trez, C. Sabatel, F. Bureau, S. De Prins, P. Percier, O. Denis, F. Jurion, M. Romano, J. M. Vanderwinden, J. J. Letesson and E. Muraille (2018). Front Immunol 9: 1856.

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells. Ghosh, S., S. Scozzaro, A. R. Ramos, S. Delcambre, C. Chevalier, P. Krejci and C. Erneux (2018). J Cell Sci.

Embryonic microglia derive from primitive macrophages and are replaced by cmyb-dependent definitive microglia in zebrafish. Giuliano Ferrero, Christopher B. Mahony, Eléonore Dupuis, Laurent Yvernogeau, Elodie Di Ruggiero, Magali Miserocchi, Marianne Caron, Catherine Robin, David Traver, Julien Y. Bertrand and Valérie Wittamer. Cell Rep. 2018 Jul 3;24(1):130-141. doi: 10.1016/j.celrep.2018.05.066.

YAP and TAZ are essential for basal and squamous cell carcinoma initiation. Debaugnies M, Sánchez-Danés A, Rorive S, Raphaël M, Liagre M, Parent MA, Brisebarre A, Salmon I, Blanpain C. EMBO Rep. 2018 Jun 6. pii: e45809. doi: 10.15252/embr.201845809. [Epub ahead of print]

A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Trubiroha A1,2, Gillotay P1, Giusti N1, Gacquer D1, Libert F1, Lefort A1, Haerlingen B1, De Deken X1, Opitz R3,4, Costagliola S5.Sci Rep. 2018 Apr 4;8(1):5647. doi: 10.1038/s41598-018-24036-4.

Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation. Suzuki IK, Gacquer D, Van Heurck R, Kumar D, Wojno M, Bilheu A, Herpoel A, Lambert N, Cheron J, Polleux F, Detours V, Vanderhaeghen P. Cell. 2018 May 31;173(6):1370-1384.e16. doi: 10.1016/j.cell.2018.03.067. Epub 2018 May 31. PMID: 29856955


Early lineage segregation of multipotent embryonic mammary gland progenitors. Wuidart A, Sifrim A, Fioramonti M, Matsumura S, Brisebarre A, Brown D, Centonze A, Dannau A, Dubois C, Van Keymeulen A, Voet T, Blanpain C. Nat Cell Biol. 2018 May 21. doi: 10.1038/s41556-018-0095-2. PMID: 29784918

Universality of clone dynamics during tissue development. Rulands S, Lescroart F, Chabab S, Hindley CJ, Prior N, Sznurkowska MK, Huch M, Philpott A, Blanpain C, Simons BD. Nat Phys. 2018 May;14(5):469-474. doi: 10.1038/s41567-018-0055-6. Epub 2018 Feb 26. PMID: 29736183

3D imaging in the postmortem human brain with CLARITY and CUBIC Ando K., Laborde Q., Brion JP and Duckaerts C. Handb. Clin. Neurol. 150:303-317. 2018.

Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq. Lescroart F, Wang X, Lin X, Swedlund B, Gargouri S, Sanchez-Danes A, Moignard V, Dubois C, Paulissen C, Kinston S, Gottgens B and Blanpain C.  Science. 2018.

2017

Tonically Active a2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons.
Molchanova SM1, Comhair J1,2, Karadurmus D1, Piccart E2, Harvey RJ3,4, Rigo JM2, Schiffmann SN1, Brône B2, Gall D1.Front Mol Neurosci. 2018 Jan 9;10:442. doi: 10.3389/fnmol.2017.00442. eCollection 2017.

Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects.
Ghosh S, Huber C, Siour Q, Sousa SB, Wright M, Cormier-Daire V, Erneux C.
Hum Mutat. 2017 Dec;38(12):1731-1739. doi: 10.1002/humu.23321. PMID: 28869677

Scaffold-Based and Scaffold-Free Testicular Organoids from Primary Human Testicular Cells.
Baert Y, Rombaut C, Goossens E.
Methods Mol Biol. 2017 Jul 4. doi: 10.1007/7651_2017_48. PMID: 28674937

Lineage-Restricted Mammary Stem Cells Sustain th Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage. Van Keymeulen A., Fioramonti M, Centonze A, Bouvencourt G, Achouri Y, Blanpain C. , Cell Rep. 2017 Aug 15;20(7):1525-1532. doi: 10.1016/j. celrep.2017.07.066

MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis. Lipski DA, Dewispelaere R., Foucart V., Caspers LE, Defrance M., Bruyns C. and Willermain F., J. Neuroinflammation. 2017 Jul 18. doi: 10.1186/s12974-017-0915-5.

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST). Vandenberghe P, Hagué P, Hockman SC, Manganiello VC, Demetter P, Erneux C and Vanderwinden JM., Oncotarget. 2017 Apr 10. doi: 10.18632/oncotarget.17010. [Epub ahead of print]

Primary Human Testicular Cells Self-Organize into Organoids with Testicular Properties. Baert Y., De Kock Y., Alves-Lopes J.P., Soder O., Stukenborg J.B. and Goossens E., Stem Cell Reports 8(1): 30-38. 2017.

Defining stem cell dynamics and migration during wound healing in mouse skin epidermis. Aragona M, Dekoninck S, Rulands S, Lenglez S, Mascré G, Simons BD, Blanpain C.Nat Commun. 2017 Mar 1;8:14684. doi: 10.1038/ncomms14684. PMID:    28248284

2016

Thrombospondin 1 protects pancreatic beta-cells from lipotoxicity via the PERK-NRF2 pathway. Cunha DA, Cito M, Carlsson PO, Vanderwinden JM, Molkentin JD, Bugliani M, Marchetti P, Eizirik DL, Cnop M., Cell Death Differ. 2016 Sep 2 doi: 10.1038/cdd.2016.89 [Epub ahead of print] PMID: 27588705.

BiDiFuse: a FIJI plugin for fusing bi-directionally recorded microscopic image volumes. Detrez, J. R., Vanderwinden, J. M., Barbier, M., Verschuuren, M., Nuydens, R., Langlois, X., Timmermans, J. P., and De Vos, W. H. Bioinformatics.  8-8-2016.

Defining the clonal dynamics leading to mouse skin tumour initiation.
Sánchez-Danés A, Hannezo E, Larsimont JC, Liagre M, Youssef KK, Simons BD, Blanpain C.
Nature. 2016 Jul 8. doi: 10.1038/nature19069. [Epub ahead of print]MID: 27459053

Early-onset Purkinje cell dysfunction underlies cerebellar ataxia in peroxisomal multifunctional protein-2 deficiency.
De Munter S, Verheijden S, Vanderstuyft E, Malheiro AR, Brites P, Gall D, Schiffmann SN, Baes M.
Neurobiol Dis. 2016 Jun 25;94:157-168. doi: 10.1016/j.nbd.2016.06.012. [Epub ahead of print]

F1.mediumQuantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells.
Wuidart A., Ousset M., Rulands S., Simons BD, Van Keymeulen A., Blanpain C.
Genes Dev. 2016 jun 1;30(11):1261-77. doi:10.1101/gad/280057.116. Epub 2016 Jun 9.


The SHIP2 interactor Myo1c is required for cell migration in 1321 N1 glioblastoma cells.
Edimo WE, Ramos AR, Ghosh S, Vanderwinden JM, Erneux C.
Biochem Biophys Res Commun. 2016 May 28. pii: S0006-291X(16)30904-4. doi: 10.1016/j.bbrc.2016.05.154. [Epub ahead of print]

Striatopallidal Neuron NMDA Receptors Control Synaptic Connectivity, Locomotor, and Goal-Directed Behaviors.
Lambot L, Chaves Rodriguez E, Houtteman D, Li Y, Schiffmann SN, Gall D, de Kerchove d’Exaerde A. J Neurosci. 2016 May 4;36(18):4976-92. doi: 10.1523/j. Neurosci..2717-15.2016. PMID: 27147651

Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis.
Chabab S, Lescroart F, Rulands S, Mathiah N, Simons BD, Blanpain C.Cell Rep. 2016 Jan 5;14(1):1-10. doi: 10.1016/j.celrep.2015.12.013. Epub 2015 Dec 24. PMID: 26725109

Mesp1 controls the speed, polarity, and directionality of cardiovascular progenitor migration.
Chiapparo G, Lin X, Lescroart F, Chabab S, Paulissen C, Pitisci L, Bondue A, Blanpain C., J. Cell Biol. 2016 May 23;213(4):463-77.doi: 10.1083/jcb.201505082. Epub 2016 May 16. PMID: 27185833

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma,
Edimo, W. E., Ghosh, S., Derua, R., Janssens, V., Waelkens, E., Vanderwinden, J. M., Robe, P., and Erneux, J. Cell Sci. 2016 Jan 29. doi: 10.1242/jcs.179663 [Epub ahead of print] PMID: 26826186

2015
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis.
Serçin Ö, Larsimont JC, Karambelas AE, Marthiens V, Moers V, Boeckx B, Le Mercier M, Lambrechts D, Basto R, Blanpain C. Nat Cell Biol. 2015 Nov 23. doi: 10.1038/ncb3270. [Epub ahead of print] PMID: 26595384

In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice.
Hanot Mambres, D., Machelart, A., Vanderwinden, J. M., De Trez, C., Ryffel, B., Letesson, J. J., and Muraille, E. PLoS One. 2015 Sep 16;10(9):e0137835. doi: 10.1371/journal.pone.0137835. eCollection 2015. PMID: 26376185

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.
Van Keymeulen A, Lee MY, Ousset M, Brohée S, Rorive S, Giraddi RR, Wuidart A, Bouvencourt G, Dubois C, Salmon I, Sotiriou C, Phillips WA, Blanpain C. Nature. 2015 Aug 12. doi: 10.1038/nature14665. [Epub ahead of print] PMID: 26266985

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output.
Chávez M, Ena S, Van Sande J, de Kerchove d’Exaerde A, Schurmans S, Schiffmann SN. Dev Cell. 2015 Jul 14. pii: S1534-5807(15)00423-2. doi: 10.1016/j.devcel.2015.06.016. PMID: 26190144

ICAM-1 and VCAM-1 are differentially expressed on blood-retinal barrier cells during experimental autoimmune uveitis.
Dewispelaere R, Lipski D, Foucart V, Bruyns C, Frère A, Caspers L, Willermain F. Exp Eye Res. 2015 Jun 17;137:94-102. doi: 10.1016/j.exer.2015.06.017. [Epub ahead of print] PMID: 26093277

Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion.
Larsimont JC, Youssef KK, Sanchez-Danes A, Sukumaran V, Defrance M, Delatte B, Liagre M, Baatsen P, Marine JC, Lippens S, Guerin C, Del M, V, Vanderwinden JM, Fuks F, Blanpain C. Cell Stem Cell 2015 Jun 16. pii: S1934-5909(15)00217-9. doi: 10.1016/j.stem.2015.05.008. [Epub ahead of print] PMID: 26095047

Organ-specific neurodegeneration in triple A syndrome-related achalasia.
Zimmer V, Vanderwinden JM, Zimmer A, Ostertag D, Strittmatter M, Koehler K, Huebner A, Lammert F. Am J Med. 2015 May 22;. [Epub ahead of print] PMID: 26007668

Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice.
Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. PLoS One. 2015 Apr 29;10(4):e0124861. doi: 10.1371/journal.pone.0124861. eCollection 2015.

Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells.
Koenig S, Moreau C, Dupont G, Scoumanne A, Erneux C. FEBS J. 2015 Apr 17. doi: 10.1111/febs.13300. [Epub ahead of print] PMID: 25892505

Area-specific reestablishment of damaged circuits in the adult cerebral cortex by cortical neurons derived from mouse embryonic stem cells.
Michelsen KA, Acosta-Verdugo S, Benoit-Marand M, Espuny-Camacho I, Gaspard N, Saha B, Gaillard A, Vanderhaeghen P. Neuron. 2015 Mar 4;85(5):982-97. doi: 10.1016/j.neuron.2015.02.001. PMID: 25741724.

2014
A BCL6/BCOR/SIRT1 Complex Triggers Neurogenesis and Suppresses Medulloblastoma by Repressing Sonic Hedgehog Signaling.
Tiberi L, Bonnefont J, van den Ameele J, Le Bon SD, Herpoel A, Bilheu A, Baron BW, Vanderhaeghen P. Cancer Cell. 2014 Dec 8;26(6):797-812. doi: 10.1016/j.ccell.2014.10.021. PMID: 25490446

Subcellular structural plasticity caused by the absence of the fast Ca2+ buffer calbindin D-28k in recurrent collaterals of cerebellar Purkinje neurons.
Orduz D, Boom A, Gall D, Brion JP, Schiffmann SN, Schwaller B. Front Cell Neurosci. 2014 Nov 5;8:364. eCollection 2014. PMID: 25414639

Functional Zebrafish Studies Based on Human Genotyping Point to Netrin-1 as a Link Between Aberrant Cardiovascular Development and Thyroid Dysgenesis.
Opitz R, Hitz MP, Vandernoot I, Trubiroha A, Abu-Khudir R, Samuels M, Désilets V, Costagliola S, Andelfinger G, Deladoëy J. Endocrinology. 2014 Oct 29:en20141628. PMID: 25353184

Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development.
Lescroart F, Chabab S, Lin X, Rulands S, Paulissen C, Rodolosse A, Auer H, Achouri Y, Dubois C, Bondue A, Simons BD, Blanpain C. Nat Cell Biol. 2014 Sep;16(9):829-40. doi: 10.1038/ncb3024. Epub 2014 Aug 24. PMID: 25150979

Brucella melitensis invades murine erythrocytes during infection.
Vitry MA, Hanot Mambres D, Deghelt M, Hack K, Machelart A, Lhomme F, Vanderwinden JM, Vermeersch M, De Trez C, Pérez-Morga D, Letesson JJ, Muraille E. Infect Immun. 2014 Jul 7. pii: IAI.01779-14. PMID: 25001604

Three-dimensional visualization of termite (Apicotermitinae) enteric valve using confocal laser scanning microscopy.
Host B, Twyffels L, Roisin Y, Vanderwinden JM. J Microsc. 2014 Jun 19. doi: 10.1111/jmi.12146. PMID:24947115

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma.
Boumahdi S, Driessens G, Lapouge G, Rorive S, Nassar D, Le Mercier M, Delatte B, Caauwe A, Lenglez S, Nkusi E, Brohée S, Salmon I, Dubois C, Marmol VD, Fuks F, Beck B, Blanpain C. Nature. 2014 Jun 8. doi: 10.1038/nature13305. PMID:24909994

Phosphorylated SHIP2 on Y1135 localizes at focal adhesions and at the mitotic spindle in cancer cell lines.
Deneubourg L, Elong Edimo W, Moreau C, Vanderwinden JM, Erneux C. Cell Signal. 2014 Feb 19. pii: S0898-6568(14)00065-5. doi: 10.1016/j.cellsig.2014.02.005. PMID:24561238

2013

Ephrin-b1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration.
Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Lie DC, Jossin Y, Vanderhaeghen P. Neuron. 2013 Sep 18;79(6):1123-35. doi: 10.1016/j.neuron.2013.07.015.

Parvalbumin tunes spike-timing and efferent short-term plasticity in striatal fast spiking interneurons.
Orduz D, Bischop DP, Schwaller B, Schiffmann SN, Gall D. J Physiol. 2013 Jul 1;591(Pt 13):3215-32. doi: 10.1113/jphysiol.2012.250795.

FACS Array Profiling Identifies Ecto-5′ Nucleotidase as a Striatopallidal Neuron-Specific Gene Involved in Striatal-Dependent Learning.
Ena SL, De Backer JF, Schiffmann SN, de Kerchove d’Exaerde A.
J Neurosci. 2013 May 15;33(20):8794-809. doi: 10.1523/JNEUROSCI.2989-12.2013. PMID:23678122

Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.
Klein S, Seidler B, Kettenberger A, Sibaev A, Rohn M, Feil R, Allescher HD, Vanderwinden JM, Hofmann F, Schemann M, Rad R, Storr MA, Schmid RM, Schneider G, Saur D.
Nat Commun. 2013 Mar 27;4:1630. doi: 10.1038/ncomms2626. PMID:23535651

A role for Sv2c in basal ganglia functions.
Dardou D, Monlezun S, Foerch P, Courade JP, Cuvelier L, De Ryck M, Schiffmann SN.
Brain Res. 2013 Feb 28. doi:pii: S0006-8993(13)00276-X. 10.1016/j.brainres.2013.02.041.

Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo.
Espuny-Camacho I, Michelsen KA, Gall D, Linaro D, Hasche A, Bonnefont J, Bali C, Orduz D, Bilheu A, Herpoel A, Lambert N, Gaspard N, Péron S, Schiffmann SN, Giugliano M, Gaillard A, Vanderhaeghen P.
Neuron. 2013 Feb 6;77(3):440-56. doi: 10.1016/j.neuron.2012.12.011

BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C.
Genes Dev. 2013 Jan 1;27(1):39-51. doi: 10.1101/gad.206573.112. Epub 2012 Dec 27

 2012

Neuronal Nogo-A negatively regulates dendritic morphology and synaptic transmission in the cerebellum.
Petrinovic MM, Hourez R, Aloy EM, Dewarrat G, Gall D, Weinmann O, Gaudias J, Bachmann LC, Schiffmann SN, Vogt KE, Schwab ME.
Proc Natl Acad Sci U S A. 2012 Dec 31.
PMID: 23277570

Transgenic zebrafish illuminate the dynamics of thyroid morphogenesis and its relationship to cardiovascular development.
Opitz R, Maquet E, Huisken J, Antonica F, Trubiroha A, Pottier G, Janssens V, Costagliola S.
Dev Biol. 2012 Dec 15;372(2):203-16. doi:10.1016/j.ydbio.2012.09.011. Epub 2012 Sep 26.

Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation.
Kass Youssef K, Lapouge G,Bouvree K, Rorive S, Brohée S, Appelstein O Larsimont JC, Sukumaran V, Van de Sande B, Pucci D, Dekoninck S, Berthe JV, Aerts S, Salmon I, Del Marmol V, Blanpain C.
Nat Cell Biol. Published online: 25 November 2012 doi/10.1038/ncb2628.

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.
Tiberi L, van den Ameele J, Dimidschstein J, Piccirilli J, Gall D, Herpoel A, Bilheu A, Bonnefont J, Iacovino M, Kyba M, Bouschet T, Vanderhaeghen P.
Nat Neurosci. 2012 Nov 18. doi: 10.1038/nn.3264. PMID: 23160044

Multipotent and unipotent progenitors contribute to prostate postnatal development.
Ousset M, Van Keymeulen A, Bouvencourt G, Sharma N, Achouri Y, Simons BD, Blanpain C.
Nat Cell Biol. 2012 Nov;14(11):1131-8. doi: 10.1038/ncb2600. Epub 2012 Oct 14. PMID: 23064263

Generation of functional thyroid from embryonic stem cells.
Antonica F, Kasprzyk DF, Opitz R, Iacovino M, Liao XH, Dumitrescu AM, Refetoff S, Peremans K, Manto M, Kyba M, Costagliola S.
Nature. 2012 Oct 10. doi: 10.1038/nature11525. PMID: 23051751

Distinct contribution of stem and progenitor cells to epidermal maintenance.
Mascré G, Dekoninck S, Drogat B, Youssef KK, Broheé S, Sotiropoulou PA, Simons BD, Blanpain C.
Nature. 2012 Sep 13;489(7415):257-62. PMID: 22940863

SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts.
Elong Edimo W, Vanderwinden JM, Erneux C.
Adv Biol Regul. 2012 Sep 13. pii: S2212-4926(12)00087-5. doi: 10.1016/j.jbior.2012.09.003. PMID: 23040614

Defining the mode of tumour growth by clonal analysis.
Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C.
Nature. 2012 Aug 23;488(7412):527-30. PMID: 22854777

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis.
Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, Cnop M.
Diabetes. 2012 Jul 6. PMID: 22773666

In Situ Microscopy Analysis Reveals Local Innate Immune Response Developed around Brucella Infected Cells in Resistant and Susceptible Mice.
Copin R, Vitry MA, Hanot Mambres D, Machelart A, De Trez C, Vanderwinden JM, Magez S, Akira S, Ryffel B, Carlier Y, Letesson JJ, Muraille E.
PLoS Pathog. 2012 Mar;8(3):e1002575. Epub 2012 Mar 29. PMID: 22479178

ENDOGLIN/CD105 is expressed in KIT positive cells in the gut and in gastrointestinal stromal tumours.
Gromova P, Rubin BP, Thys A, Cullus P, Erneux C, Vanderwinden JM.
J Cell Mol Med. 2012 Feb;16(2):306-17. doi: 10.1111/j.1582-4934.2011 .01315.x. PMID: 21435173

2011

Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions.
Durieux PF, Schiffmann SN, de Kerchove d’Exaerde A.
EMBO J. 2011 Nov 8;31(3):640-53. doi: 10.1038/emboj.2011.400.

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours.
Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, Caauwe A, Sotiropoulou PA, Loges S, Lapouge G, Candi A, Mascre G, Drogat B, Dekoninck S, Haigh JJ, Carmeliet P, Blanpain C.
Nature. 2011 Oct 19;478(7369):399-403. doi: 10.1038/nature10525.

Distinct stem cells contribute to mammary gland development and maintenance.
Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, Sharma N, Dekoninck S, Blanpain C.
Nature. 2011 Oct 9;479(7372):189-93. doi: 10.1038/nature10573.

Long live sox2: sox2 lasts a lifetime.
Driessens G, Blanpain C.
Cell Stem Cell. 2011 Oct 4;9(4):283-4. doi: 10.1016/j.stem.2011.09.007.

Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.
Hourez R, Servais L, Orduz D, Gall D, Millard I, de Kerchove d’Exaerde A, Cheron G, Orr HT, Pandolfo M, Schiffmann SN.
J Neurosci. 2011 Aug 17;31(33):11795-807.

Identifying the cellular origin of squamous skin tumors.
Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, Sotiropoulou PA, Blanpain C.
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7431-6. Epub 2011 Apr 18.

Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin.
van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, Kyba M, Blanpain C, Vanderhaeghen P.
EMBO Rep. 2012 Mar 9;13(4):355-362. doi: 10.1038/embor.2012.23.

Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation.
Bondue A, Tännler S, Chiapparo G, Chabab S, Ramialison M, Paulissen C, Beck B, Harvey R, Blanpain C.
J Cell Biol. 2011 Mar 7;192(5):751-65.

Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on the basal ganglia system.
Dardou D, Dassesse D, Cuvelier L, Deprez T, De Ryck M, Schiffmann SN.
Brain Res. 2011 Jan 7;1367:130-45. Epub 2010 Sep 22.

2010

Mesp1: a key regulator of cardiovascular lineage commitment.
Bondue A, Blanpain C.
Circ Res. 2010 Dec 10;107(12):1414-27. Review.

Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells.
Jiang L, Allagnat F, Nguidjoe E, Kamagate A, Pachera N, Vanderwinden JM, Brini M, Carafoli E, Eizirik DL, Cardozo AK, Herchuelz A.
J Biol Chem. 2010 Oct 1;285(40):30634-43. Epub 2010 Jul 26.

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress.
Gurzov EN, Germano CM, Cunha DA, Ortis F, Vanderwinden JM, Marchetti P, Zhang L, Eizirik DL.
J Biol Chem. 2010 Jun 25;285(26):19910-20. Epub 2010 Apr 26.

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death.
Sotiropoulou PA, Candi A, Mascré G, De Clercq S, Youssef KK, Lapouge G, Dahl E, Semeraro C, Denecker G, Marine JC, Blanpain C.
Nat Cell Biol. 2010 Jun;12(6):572-82. Epub 2010 May 16.

PGC-1alpha down-regulation affects the antioxidant response in Friedreich’s ataxia.
Marmolino D, Manto M, Acquaviva F, Vergara P, Ravella A, Monticelli A, Pandolfo M.
PLoS One. 2010 Apr 7;5(4):e10025.

NatureCellBiology1003
Identification of the cell lineage at the origin of basal cell carcinoma.
Youssef KK, Van Keymeulen A, Lapouge G, Beck B, Michaux C, Achouri Y, Sotiropoulou PA, Blanpain C.
Nat Cell Biol. 2010 Mar;12(3):299-305. Epub 2010 Feb 14.

Nucleoside analog stavudine depletes mitochondrial DNA with no organelle loss in mouse oocytes.
Bostan A, Demeestere I, Vanderwinden JM, Devreker F, Englert Y.
Curr HIV Res. 2010 Mar;8(2):127-33.

Fusogenic activity of cationic lipids and lipid shape distribution.
Lonez C, Lensink MF, Kleiren E, Vanderwinden JM, Ruysschaert JM, Vandenbranden M.
Cell Mol Life Sci. 2010 Feb;67(3):483-94. Epub 2009 Nov 19.

2009

Grafting neural precursor cells promotes functional recovery in an SCA1 mouse model.
Chintawar S, Hourez R, Ravella A, Gall D, Orduz D, Rai M, Bishop DP, Geuna S, Schiffmann SN, Pandolfo M.
J Neurosci. 2009 Oct 21;29(42):13126-35.

JCB091005
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis.
Van Keymeulen A, Mascre G, Youseff KK, Harel I, Michaux C, De Geest N, Szpalski C, Achouri Y, Bloch W, Hassan BA, Blanpain C.
J Cell Biol. 2009 Oct 5;187(1):91-100. Epub 2009 Sep 28.

Generation of cortical neurons from mouse embryonic stem cells.
Gaspard N, Bouschet T, Herpoel A, Naeije G, van den Ameele J, Vanderhaeghen P.
Nat Protoc. 2009 Sep;4(10):1454-63. Epub 2009 Sep 17.

Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion.
Azdad K, Chàvez M, Don Bischop P, Wetzelaer P, Marescau B, De Deyn PP, Gall D, Schiffmann SN.
PLoS One. 2009 Sep 4;4(9):e6908.

Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.
Gromova P, Ralea S, Lefort A, Libert F, Rubin BP, Erneux C, Vanderwinden JM.
J Cell Mol Med. 2009 Aug;13(8A):1536-48. Epub 2009 May 19.

Blood-brain barrier promotes differentiation of human fetal neural precursor cells.
Chintawar S, Cayrol R, Antel J, Pandolfo M, Prat A.
Stem Cells. 2009 Apr;27(4):838-46.

2008

An intrinsic mechanism of corticogenesis from embryonic stem cells.
Gaspard N, Bouschet T, Hourez R, Dimidschstein J, Naeije G, van den Ameele J, Espuny-Camacho I, Herpoel A, Passante L, Schiffmann SN, Gaillard A, Vanderhaeghen P.
Nature. 2008 Sep 18;455(7211):351-7. Epub 2008 Aug 17.

Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.
Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C.
Cell Stem Cell. 2008 Jul 3;3(1):69-84.

Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum.
Passante L, Gaspard N, Degraeve M, Frisén J, Kullander K, De Maertelaer V, Vanderhaeghen P.
Development. 2008 Oct;135(19):3281-90. Epub 2008 Aug 28.

The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.
Onnockx S, De Schutter J, Blockmans M, Xie J, Jacobs C, Vanderwinden JM, Erneux C, Pirson I.
J Cell Physiol. 2008 Jan;214(1):260-72.

The majority of multipotent epidermal stem cells do not protect their genome by asymmetrical chromosome segregation.
Sotiropoulou PA, Candi A, Blanpain C.
Stem Cells. 2008 Nov;26(11):2964-73. Epub 2008 Sep 4.

Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington’s disease.
Bantubungi K, Blum D, Cuvelier L, Wislet-Gendebien S, Rogister B, Brouillet E, Schiffmann SN.
Mol Cell Neurosci. 2008 Mar;37(3):454-70. Epub 2007 Nov 12.

2007

Expression of Cre recombinase in dopaminoceptive neurons.
Lemberger T, Parlato R, Dassesse D, Westphal M, Casanova E, Turiault M, Tronche F, Schiffmann SN, Schütz G.
BMC Neurosci. 2007 Jan 3;8:4.

The distribution of interstitial cells of Cajal in the ileum is not altered by infection with Schistosoma mansoni.
Chatterjee S, Vrolix G, Van Marck E, Vanderwinden JM.
J Vector Borne Dis. 2007 Jun;44(2):90-7.

2006

Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB.
Steuve S, Devosse T, Lauwers E, Vanderwinden JM, André B, Courtoy PJ, Pirson I.
Exp Cell Res. 2006 Dec 10;312(20):3981-9. Epub 2006 Sep 9.

Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker.
Wouters M, De Laet A, Donck LV, Delpire E, van Bogaert PP, Timmermans JP, de Kerchove d’Exaerde A, Smans K, Vanderwinden JM.
Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1219-27. Epub 2005 Aug 25.

Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions.
Bearzatto B, Servais L, Roussel C, Gall D, Baba-Aïssa F, Schurmans S, de Kerchove d’Exaerde A, Cheron G, Schiffmann SN.
FASEB J. 2006 Feb;20(2):380-2. Epub 2005 Dec 13.

2005

Accelerated intestinal transit in inbred mice with an increased number of interstitial cells of Cajal.
Bellier S, Da Silva NR, Aubin-Houzelstein G, Elbaz C, Vanderwinden JM, Panthier JJ.
Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G151-8. Epub 2004 Aug 5. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G172.

Contribution of the carboxyl terminus of the VPAC1 receptor to agonist-induced receptor phosphorylation, internalization, and recycling.
Langlet C, Langer I, Vertongen P, Gaspard N, Vanderwinden JM, Robberecht P.
J Biol Chem. 2005 Jul 29;280(30):28034-43. Epub 2005 Jun 2.

Differences in signaling pathways and expression level of the phosphoinositide phosphatase SHIP1 between two oncogenic mutants of the receptor tyrosine kinase KIT.
Vanderwinden JM, Wang D, Paternotte N, Mignon S, Isozaki K, Erneux C.
Cell Signal. 2006 May;18(5):661-9. Epub 2005 Jun 28.

Ephrin signalling controls brain size by regulating apoptosis of neural progenitors.
Depaepe V, Suarez-Gonzalez N, Dufour A, Passante L, Gorski JA, Jones KR, Ledent C, Vanderhaeghen P.
Nature. 2005 Jun 30;435(7046):1244-50. Epub 2005 May 15.

Interstitial cells of Cajal are involved in the afferent limb of the rectoanal inhibitory reflex.
de Lorijn F, de Jonge WJ, Wedel T, Vanderwinden JM, Benninga MA, Boeckxstaens GE.
Gut. 2005 Aug;54(8):1107-13.

SHIP2 interaction with the cytoskeletal protein Vinexin.
Paternotte N, Zhang J, Vandenbroere I, Backers K, Blero D, Kioka N, Vanderwinden JM, Pirson I, Erneux C.
FEBS J. 2005 Dec;272(23):6052-66.

Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice.
Niessen P, Rensen S, van Deursen J, De Man J, De Laet A, Vanderwinden JM, Wedel T, Baker D, Doevendans P, Hofker M, Gijbels M, van Eys G.
Gastroenterology. 2005 Nov;129(5):1592-601.

Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker.
Wouters M, De Laet A, Donck LV, Delpire E, van Bogaert PP, Timmermans JP, de Kerchove d’Exaerde A, Smans K, Vanderwinden JM.
Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1219-27. Epub 2005 Aug 25.

The Polycomb group protein EZH2 directly controls DNA methylation.
Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F.
Nature. 2006 Feb 16;439(7078):871-4. Epub 2005 Dec 14. Erratum in: Nature. 2007 Apr 12;446(7137):824.

WZsGreen/+: a new green fluorescent protein knock-in mouse model for the study of KIT-expressing cells in gut and cerebellum.
Wouters M, Smans K, Vanderwinden JM.
Physiol Genomics. 2005 Aug 11;22(3):412-21. Epub 2005 Jun 14.

2004

Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3.
Sokolow S, Manto M, Gailly P, Molgó J, Vandebrouck C, Vanderwinden JM, Herchuelz A, Schurmans S.
J Clin Invest. 2004 Jan;113(2):265-73.